Distribution of glucose transporters in renal diseases

Distribution of the glucose transporters in human brain tumors.

In the present study, we have investigated the expression of both the erythrocyte-type (GLUT1) and the brain-type (GLUT3) glucose transporter isoforms in primary human brain tumors. In situ hybridization made it possible to localize and semiquantify both GLUT1 and GLUT3 mRNAs of individual cells in all 18 samples examined. More signals for GLUT3 mRNA than for GLUT1 mRNA were found over astrocyt...

Glucose transporters in obesity

L’obCsitC, pathologie frtquente dans les sociCtCs industrialiskes, est caractQiste par un sur-diveloppement du tissu adipeux. Nous avons CtudiC un moditle animal d’obksitk, le rat Zucker gCnCtiquement obkse. D b l’iige de 30 jours, les cellules adipeuses des rats mutants transportent beaucoup plus de glucose que celles des temoins normaux des memes portCes. Cette anomalie repose sur une augment...

Glucose transporters in preimplantation development.

The inability of the embryo to utilize glucose as a fuel before compaction has been an area of much speculation. It is suggested that limitations in glucose transporter processes are the prime reasons for this. The recent identification of GLUT3 as the transporter responsible for the uptake of maternal glucose after compaction may provide the missing link in this puzzle. Furthermore, the coinci...

Glucose transporters in mammalian brain.

(;lucose is the primary energy source for mammalian brain and a continuous supply is vital for normal cerebral function. At rest, the brain is responsible for metabolizing up to 60% of the available circulating glucose, and the efficient transport of glucose across the blood-brain barrier (BRH) and into the various cells that make up the brain is essential. Of the six facilitative glucose trans...

Targeting of mammalian glucose transporters.